PRISMA 2020 Systematic Review & GRADE Certainty Appraisal in Obstetrics

1. Scientific Context & Challenge

A clinician-researcher needed to conduct a rigorous systematic review on a rare obstetrics condition for peer-reviewed publication, but lacked internal methodological bandwidth for multi-database search design, blinded dual-reviewer screening, GRADE certainty assessment, and full manuscript drafting alongside active clinical duties.

2. Methodological Approach

We developed a structured PICO protocol and executed reproducible search strategies across PubMed/MEDLINE, Embase, and Cochrane Library with full search-string documentation. Blinded dual-reviewer title/abstract and full-text screening was performed in Rayyan with a complete conflict-resolution audit log. Standardized extraction templates, Cochrane Risk-of-Bias appraisal, and outcome-level GRADE certainty profiles were completed prior to manuscript drafting.

3. Solution Architecture

Turnkey methodological execution and publication-grade medical writing that preserved the clinician-investigator’s intellectual leadership while guaranteeing full PRISMA 2020 and GRADE compliance.

4. Verified Outcome

Delivered a submission-ready manuscript package complete with PRISMA 2020 flow diagram, 27-item checklist, supplementary search tables, Risk-of-Bias traffic-light plots, and GRADE summary-of-findings tables. The clinician-investigator retained first and senior authorship; Science Habitat’s methodological and writing contributions were transparently acknowledged in accordance with ICMJE guidelines.

Engagement Specifications

Timeline / Date

12–14 weeks

Scientific Team

2 PhD Scientists

Scope Classification

End-to-end PRISMA 2020 systematic review & ICMJE-compliant manuscript preparation

Capabilities Applied