Showing 10 verified publications (Vancouver citation format)
Frontiers in Cell and Developmental Biology (2022)
DOI: 10.3389/fcell.2022.845457 · PMID: 35433699 · PMCID: PMC9009527
Authors: Sahu D, Bishwal SC, Malik MZ, Sahu S, Kaushik SR, Sharma S, Saini E, Arya R, Rastogi A, Sharma S, Sen S, Singh RKB, Liu CJ, Nanda RK, Panda AK (First Author (Debasis Sahu, PhD))
Troxerutin (TXR) is a phytochemical reported to possess anti-inflammatory and hepatoprotective effects. In this study, we aimed to exploit the antiarthritic properties of TXR using an adjuvant-induced arthritic (AIA) rat model. AIA-induced rats showed the highest arthritis score at the disease onset and by oral…
Computational BiologyMulti-Omics & ProteomicsScientific & Medical Writing
European Journal of Pharmaceutical Sciences (2020)
DOI: 10.1016/j.ejps.2020.105424 · PMID: 32534193
Authors: Garg SS, Gupta J, Sharma S, Sahu D (Senior & Corresponding Author (Debasis Sahu, PhD) • Co-Author (Shikha Sharma, PhD))
The coumarins are heterocyclic compounds belonging to the class of benzopyrone enriched in various plants like tonka beans. Coumarins and their derivatives exert a vast array of bioactive properties such as anticoagulant, antibacterial, anti-inflammatory, antioxidant, antitumor, antiviral, and enzyme inhibition.…
Scientific & Medical WritingEvidence Synthesis & HTA
Smart Nanodevices for Point-of-Care Applications (CRC Press / Routledge, Chapter 16) (2022)
DOI: 10.1201/9781003157823-16
Authors: Garg SS, Nuthalapati P, Devi S, Sharma A, Sahu D, Gupta J (Co-Senior Author (Debasis Sahu, PhD))
Peer-reviewed book chapter in Smart Nanodevices for Point-of-Care Applications (CRC Press / Taylor & Francis Group, 2022; ISBN 9780367740245). This chapter synthesizes the molecular mechanisms linking reactive oxygen species (ROS) generation, mitochondrial dysfunction, amyloid-beta aggregation, tau…
Scientific & Medical WritingEvidence Synthesis & HTA
Frontiers in Pharmacology (2026)
DOI: 10.3389/fphar.2026.1770295 · PMID: 42147320
Authors: Van Nynatten LR, Stranges V, Sahu D, Fraser DD (Co-Author (Debasis Sahu, PhD))
Sepsis remains one of the most complex and lethal syndromes in pediatric critical care, driven by dysregulated and heterogeneous host responses to infection. Despite decades of biomarker research, few biomarkers have been translated into routine clinical use for diagnosis or prognostication. This is largely because…
Multi-Omics & ProteomicsComputational BiologyScientific & Medical Writing
Clinical Proteomics (2026)
DOI: 10.1186/s12014-026-09601-8 · PMID: 41947042
Authors: Sahu D, Van Nynatten LR, Tweddell D, Daley M, Fraser DD (First Author (Debasis Sahu, PhD))
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to significant global health burden, including both acute infections and persistent post-acute sequelae, also known as Long COVID (LC) in survivors. While clinical management has reduced…
Multi-Omics & ProteomicsComputational BiologyScientific & Medical Writing
Metabolites (2026)
DOI: 10.3390/metabo16010049 · PMID: 41590657
Authors: Sahu D, Matusa AM, DiBattista A, Urquhart BL, Fraser DD (First Author (Debasis Sahu, PhD))
Mass spectrometry-based metabolomics is a valuable tool for advancing pediatric health research. Along with nuclear magnetic resonance, it enables detailed biochemical analysis from minimal sample volumes, a critical feature for pediatric diagnosis. Metabolomics supports early detection of inherited metabolic…
Multi-Omics & ProteomicsScientific & Medical Writing
International Journal of Molecular Sciences (2025)
DOI: 10.3390/ijms27010164 · PMID: 41516041
Authors: Sahu D, Ganguly T, Mann A, Gupta Y, Van Nynatten LR, Fraser DD (First Author (Debasis Sahu, PhD))
Vascular diseases (VDs) and cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. Current diagnostic and therapeutic approaches are limited by insufficient resolution and a lack of mechanistic understanding at the cellular level. Traditional imaging and clinical assays do not…
Single-Cell & Systems BiologyMulti-Omics & ProteomicsScientific & Medical Writing
Scientific Reports (Nature Portfolio) (2024)
DOI: 10.1038/s41598-024-63790-6 · PMID: 38839973
Authors: Sahu D, Gupta C, Yennamalli RM, Sharma S, Roy S, Hasan S, Gupta PK, Sharma VK, Kashyap S, Kumar S, Dwivedi VP, Zhao X, Panda AK, Das HR, Liu CJ (First Author (Debasis Sahu, PhD) • Co-Author (Shikha Sharma, PhD))
The inhibition of tumor necrosis factor (TNF)-α trimer formation renders it inactive for binding to its receptors, thus mitigating the vicious cycle of inflammation. We designed a peptide (PIYLGGVFQ) that simulates a sequence strand of human TNFα monomer using a series of in silico methods, such as active site finding…
Computational BiologyScientific & Medical Writing
International Journal of Molecular Sciences (2022)
DOI: 10.3390/ijms232012643 · PMID: 36293500
Authors: Garg SS, Gupta J, Sahu D, Liu CJ (Co-Corresponding Author (Debasis Sahu, PhD))
Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in various plants such as <i>Sonchus grandifolius</i>, <i>Aesculus turbinata</i>, etc. Free radicals lead to the development of oxidative stress causing inflammation, arthritis, cancer, diabetes, fatty liver disease, etc. These…
Scientific & Medical WritingEvidence Synthesis & HTA
European Journal of Pharmaceutical Sciences (2017)
DOI: 10.1016/j.ejps.2017.02.013 · PMID: 28189815
Authors: Sahu D, Sharma S, Singla RK, Panda AK (First Author (Debasis Sahu, PhD) • Co-Author (Shikha Sharma, PhD))
It is imperative to interrupt the link between arthritis and regulation of oxidative stress with the administration of antioxidants. Suramin is known for its anti-inflammatory, antineoplastic and antiangiogenic activities implying its possible antioxidant property. In this study, the antioxidant activity of suramin in…
Scientific & Medical WritingComputational Biology